Human Sera
Cayman Chemical 6,2',4'-Trimethoxyflavone, Purity: ≥95%, CAS: 720675-74-1, 50 mg
A flavonoid; inhibits benzo[a]pyrene-induced AhR-dependent transcription in a reporter assay at 2 and 10 µM; decreases LPS-induced production of TNF-α in THP-1 cells (IC50 = 47.7 µg/ml); inhibits cell migration and invasion of HN-30 HNSCC cells at 10 µM
Cayman Chemical Acenaphthene-d10, Purity: ≥99% deuterated forms (d1-d10), CAS: 15067-26-2, 100 mg
An internal standard for the quantification of acenaphthene by GC- or LC-MS
Cayman Chemical 5-(3'-Hydroxyphenyl)-γ-Valerolactone, Purity: ≥95%, CAS: 21618-91-7, 100 mg
A metabolite of various polyphenols
Cayman Chemical Homocitrulline, Purity: ≥95%, CAS: 1190-49-4, 100 mg
An amino acid and a product of carbamylation; protein-bound homocitrulline levels are increased in the aortas of transgenic Ldlr-/- mice expressing human MPO fed a high-fat atherogenic diet; homocitrulline-containing peptides induce the development of arthritis in mice; homocitrulline-containing peptide and anti-homocitrulline antibody levels are increased in whole blood from patients with erosive rheumatoid arthritis compared to patients with non-erosive rheumatoid arthritis
Cayman Chemical Oxotremorine (sesquifumarate), Purity: ≥95%, CAS: 17360-35-9, 100 mg
A muscarinic acetylcholine receptor agonist; binds to M1, M2, M3, and M4 mAChRs (Kis = 3.31, 9.33, 5.24, and 7.08 µM, respectively, for the human receptors); inhibits ACh release in rat cerebral cortical slices at 10 µM, an effect that can be reversed by atropine; induces tremors, salivation, and lacrimation in mice (ED50s = 0.11, 0.22, and 0.28 mg/kg); induces analgesia in the hot plate test in mice at 0.5 mg/kg; has been used to induce parkinsonian symptoms as a model of Parkinson's disease in mice
Cayman Chemical 3'-Deoxy-3'-fluoroguanosine, Purity: ≥98%, CAS: 123402-21-1, 50 mg
A nucleoside analog an inhibitor of HCV NS5B (IC50 = 1.8 µM)
Cayman Chemical Octacosanoic Acid, Purity: ≥95%, CAS: 506-48-9, 100 mg
A very long-chain saturated fatty acid and the major component of D-003
Cayman Chemical Succinimidyl 4-formylbenzoate, Purity: ≥95%, CAS: 60444-78-2, 50 mg
A heterobifunctional building block; has been used in the conjugation of oligonucleotides to antibodies for protein detection, as well as in the synthesis of fluorescent BODIPY-etoposide
Cayman Chemical Hexylglutathione, Purity: ≥95%, CAS: 24425-56-7, 100 mg
An mtMGST1 inhibitor (IC50 = 0.48 mM); inhibits the dopachrome tautomerase activity of MIF (IC50 = 3.3 mM); has been used as an affinity chromatography ligand to purify GST from sheep liver homogenate
Cayman Chemical Seralutinib, Purity: ≥98%, CAS: 1619931-27-9, 50 mg
A PDGFR, c-Kit, and CSF1R inhibitor; inhibits PDGF-BB-induced phosphorylation of ERK in H1703 cells, HPASMCs, and HLFs (IC50s = 74, 49, and 62 nM, respectively); inhibits stem cell factor-induced c-Kit autophosphorylation in HPAECs and M-CSF-induced CSF1R phosphorylation in human primary differentiated macrophages (IC50s = 7.8 and 14.4 nM, respectively); inhibits the proliferation of H1703 cells and PDGF-BB-induced HPASMCs and HLFs (IC50s = 32, 33, and 29 nM, respectively); prevents increases in pulmonary artery systolic pressure in a rat model of pulmonary arterial hypertension induced by monocrotaline pneumonectomy when administered via passive inhalation at 2.5 mg/kg
Cayman Chemical Nilvadipine, Purity: ≥98%, CAS: 75530-68-6, 100 mg
An L-type calcium channel blocker; selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM; inhibits increases in systolic blood pressure induced by chronic intravenous infusion of endothelin in rats at 10 mg/kg per day, p.o.; decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer’s disease at 0.03% (w/w) in the diet for 17 and 10 months, respectively; reduces infarct volume in a rat model of MCAO-induced focal cerebral ischemia at 3.2 mg/kg, s.c.
Cayman Chemical Panaxatriol, Purity: ≥95%, CAS: 32791-84-7, 50 mg
A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction, increases LVDevP and GSH levels, and decreases cardiac LDH, CK, and MDA levels in isolated rats at 5 mg/kg for seven consecutive days prior to injury; decreases fasting blood glucose levels in KKAy insulin-resistant mice at 0.2% in chow for 6 weeks
Cayman Chemical Irsogladine (maleate), Purity: ≥98%, CAS: 84504-69-8, 50 mg
A gastroprotective agent; increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced GJIC; inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats at 3 mg/kg, effects that can be prevented by L-NAME; inhibits fMLP-induced superoxide anion production and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to rolipram
Cayman Chemical ARUK2001607, Purity: ≥98%, CAS: 2924824-56-4, 50 mg
A PI5P4Kγ inhibitor (IC50 = 0.079 µM for PI5P4Kγ+, a construct with mutations conferring increased functional activity); selectively binds to PI5P4Kγ (Kd = 7.1 nM) over 22 other lipid kinases but does bind to PIP5K1C (Kd = 230 nM); selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >15.8 and >25.1 µM, respectively); selective for PI5P4Kγ over 138 other kinases in a kinase panel and a variety of receptors, enzymes, and ion channels in a safety panel at 10 µM but does inhibit Aurora B kinase and CLK2 by 31 and 37% and dopamine uptake by 59% at 10 µM
Cayman Chemical GSK205 (hydrobromide), Purity: ≥95%, 100 mg
A TRPV4 and TRPA1 inhibitor (IC50s = 4.19 and 5.56, respectively, for the rat channels); inhibits GSK1016790A-induced calcium influx in whole-cell patch-clamp assays using Neuro2a cells expressing TRPV4 at 5 µM; prevents compression-induced increases in NF-κB transcriptional activity and secreted levels of IL-6 and VEGFA, as well as inhibits compression-induced fractures, abnormal cell morphology, and fissures in the intervertebral space, in primary mouse lumbar spines at 10 µM